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Theoretical correction methods for optical tweezers: Acquisition of potentials of mean forces between colloidal particles in a bulk and on a surface

2020/03/24 by Ken‐ichi Amano, Amano, Ken-ichi, Rikako Suzuki +3
Chemistry · Engineering · Physics and Astronomy · #Data Analysis #Electrostatics and Colloid Interactions #FOS: Physical sciences #Microfluidic and Bio-sensing Technologies #Optics (physics.optics) #Orbital Angular Momentum in Optics #Soft Condensed Matter (cond-mat.soft) #Statistics and Probability (physics.data-an)

paper · pdf · doi:10.48550/arxiv.2003.10722

openalex publication_date 2020/03/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

It is known that line optical tweezers (LOT) can measure potential of mean force (PMF) between colloidal particles in the bulk. However, PMF obtained with LOT is empirically modified before showing the result of the final form in order to correct the potential rise at long distances. In the present letter, we derive theoretical correction methods for acquisition of PMF by using statistical mechanics. Using the new methods, PMF can be obtained without the empirical fitting equation. Through the new methods, external potential acting on the trapped two colloidal particles induced by LOT can also be obtained. As an additional study, we explain two methods for obtaining PMF between colloidal particles on a substrate surface, in which a normal single optical tweezers with a fixed focal point is used, and for obtaining PMF between colloidal particles trapped by dual-beam optical tweezers in the bulk. These methods can also obtain the external potential acting on the trapped two colloidal particles.

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