2024/04/03 by Benjamin Qureshi, Qureshi, Benjamin, Jenny M. Poulton +3
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Advanced Thermodynamics and Statistical Mechanics #Biological Physics (physics.bio-ph) #FOS: Biological sciences #FOS: Computer and information sciences #FOS: Physical sciences #Information Theory (cs.IT) #Molecular Networks (q-bio.MN) #Protein Structure and Dynamics #Spectroscopy and Quantum Chemical Studies #Statistical Mechanics (cond-mat.stat-mech)
paper · pdf · doi:10.48550/arxiv.2404.02791
openalex publication_date 2024/04/03 · openalex created_date 2024/04/06 · openalex updated_date 2026/08/03
Cells produce RNA and proteins via molecular templating networks. We show that information transmission in such networks is bounded by functions of a simple thermodynamic property of the network, regardless of complexity. Surprisingly, putative systems operating at this bound do not have a high flux around the network. Instead, they have low entropy production, with each product in a ``pseudo-equilibrium'' determined by a single pathway. These pseudo-equilibrium limits constrain information transmission for the overall network, even if individual templates are arbitrarily specific.