2025/05/14 by Cohen, Tomer, Eitan Yaakobi, Yaakobi, Eitan · 3 citations
Biochemistry, Genetics and Molecular Biology · #Advanced biosensing and bioanalysis techniques #DNA and Biological Computing #DNA and Nucleic Acid Chemistry #FOS: Computer and information sciences #H.1.1 #Information Theory (cs.IT)
paper · pdf · doi:10.48550/arxiv.2505.09533
openalex publication_date 2025/05/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
This paper studies two problems that are motivated by the novel recent approach of composite DNA that takes advantage of the DNA synthesis property which generates a huge number of copies for every synthesized strand. Under this paradigm, every composite symbols does not store a single nucleotide but a mixture of the four DNA nucleotides. The first problem studies the expected number of strand reads in order to decode a composite strand or a group of composite strands. In the second problem, our goal is study how to carefully choose a fixed number of mixtures of the DNA nucleotides such that the decoding probability by the maximum likelihood decoder is maximized.