2025/06/28 by Wietske van der Zwaag, Desmond H. Y. Tse, Benedikt A. Poser +1 · 1 voice
Neuroscience · Medicine · #Vestibular and auditory disorders #Advanced MRI Techniques and Applications #Functional Brain Connectivity Studies
paper · pdf · doi:10.1002/mrm.30596
PURPOSE: This study explored the possibility of visualizing cerebellar structure and function in vivo with a 9.4 T protocol suitable for neuroscientific experiments. METHODS: Six healthy individuals were scanned with a 9.4 T acquisition protocol including functional runs using BOLD-weighted 3D EPI at 0.8 and 1.0 mm isotropic resolution, and a 0.4 mm MP2RAGE covering the entire cerebellum to derive cerebellar cortical surfaces. RESULTS: shim over the cerebellum provided sufficient contrast for gray-white matter segmentation and surface generation in all participants. A motor-task paradigm yielded consistent responses in both hemispheres in the posterior and anterior cerebellar lobes. CONCLUSION: These experiments show that it is feasible to undertake neuroscientific experiments in the human cerebellum using 9.4 T MRI. The increased SNR and BOLD sensitivity benefit both structural and functional acquisitions and derivatives such as cortical surfaces generated from these data.