Leslie A. Lange
- Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
2021/02/10 by Daniel Taliun, Daniel Harris, Michael D. Kessler +97 · 60 citations
Biochemistry, Genetics and Molecular Biology · #Genetic Associations and Epidemiology #Genomics and Rare Diseases #RNA Research and Splicing
- Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data
2022/03/01 by Pierrick Wainschtein, Deepti Jain, Zhili Zheng +490 · 3 citations
Biochemistry, Genetics and Molecular Biology · #Genetic Associations and Epidemiology #Genetic Mapping and Diversity in Plants and Animals #Genetic and phenotypic traits in livestock
- Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
2018/11/01 by Symen Ligthart, Ahmad Vaez, Urmo Võsa +341 · 26 citations
Biochemistry, Genetics and Molecular Biology · Health Professions · Immunology and Microbiology · #1000 Genomes Project #Adolescent and Pediatric Healthcare #Bioinformatics #Biology #Biomarker #C-reactive protein #Gene #Genetic Associations and Epidemiology #Genetic association #Genetic variants #Genetics #Genome-wide association study #Genotype #IL-33, ST2, and ILC Pathways #Immunology #Inflammation #International HapMap Project #Mendelian randomization #Single-nucleotide polymorphism
- Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project
2021/11/03 by Yao Hu, Jeffrey Haessler, Regina Manansala +36 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Genetic Associations and Epidemiology #Cerebrovascular and genetic disorders #Genomics and Rare Diseases
- Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci
2012/10/11 by Folkert W. Asselbergs, Yiran Guo, Erik P.A. van Iperen +97 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Genetic Associations and Epidemiology #Genetic and phenotypic traits in livestock #Lipid metabolism and disorders
- A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies
2022/10/27 by Zilin Li, Xihao Li, Hufeng Zhou +531 · 2 citations
Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Genetic Associations and Epidemiology #Genomics and Rare Diseases
- Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies
2022/12/23 by Xihao Li, Corbin Quick, Hufeng Zhou +448 · 1 citation
Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Genetic Associations and Epidemiology #Genomics and Rare Diseases