Jérémie Rosain
- Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
2021/08/10 by Paul Bastard, Adrian Gervais, Tom Le Voyer +97 · 1 voice · 56 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #SARS-CoV-2 and COVID-19 Research #COVID-19 Clinical Research Studies #Diabetes and associated disorders
- Autoantibodies against type I IFNs in patients with life-threatening COVID-19
2020/09/24 by Paul Bastard, Lindsey B. Rosen, Qian Zhang +97 · 1 voice · 31 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #COVID-19 Clinical Research Studies #Diabetes and associated disorders #SARS-CoV-2 and COVID-19 Research
- Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
2020/09/24 by Qian Zhang, Paul Bastard, Zhiyong Liu +97 · 27 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Blood disorders and treatments #Diabetes and associated disorders #Immunodeficiency and Autoimmune Disorders
- Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine
2021/02/05 by Paul Bastard, Eleftherios Michailidis, Hans-Heinrich Hoffmann +42 · 1 voice · 12 citations
Immunology and Microbiology · Medicine · #Immune Cell Function and Interaction #Mosquito-borne diseases and control #interferon and immune responses
- Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients
2023/05/27 by Adrian Gervais, Francesca Rovida, Maria Antonietta Avanzini +59 · 1 voice · 11 citations
Immunology and Microbiology · Medicine · #Complement system in diseases #Mosquito-borne diseases and control #Viral Infections and Vectors
- The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
2022/05/16 by Jérémy Manry, Paul Bastard, Adrian Gervais +97 · 1 voice · 5 citations
Medicine · #COVID-19 Clinical Research Studies #Long-Term Effects of COVID-19 #SARS-CoV-2 and COVID-19 Research
- Negative selection on human genes underlying inborn errors depends on disease outcome and both the mode and mechanism of inheritance
2021/01/06 by Franck Rapaport, Bertrand Boisson, Anne Gregor +13 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Genetics and Neurodevelopmental Disorders #Genomics and Rare Diseases #Neurogenetic and Muscular Disorders Research
- Type I IFN autoantibodies underlie chikungunya live-attenuated vaccine encephalitis
2026/01/22 by A. Gervais, Paul Bastard, Qian Zhang +19 · 1 voice · 7 citations
Medicine · Immunology and Microbiology · #Mosquito-borne diseases and control #Autoimmune Neurological Disorders and Treatments #interferon and immune responses
- Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2)
2026/07/16 by Conor Gruber, Meredith Ramba, Bineeta Debnath +38 · 1 voice
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Immunodeficiency and Autoimmune Disorders #Inflammasome and immune disorders #interferon and immune responses